Objective: Migraine with aura (MwA) is associated with a 2-fold risk of ischemic stroke. Chiang 6 1Mayo Clinic, Neurology, Scottsdale, AZ, United States 2Mayo Clinic, Cardiology, Scottsdale, AZ, United States 3Mayo Clinic, Quantitative Health Research, Scottsdale, AZ, United States 4Mayo Clinic, Neurology, Mankato, MN, United States 5Mayo Clinic, Cardiology, Rochester, MN, United States 6Mayo Clinic, Neurology, Rochester, MN, United States Correspondence: N. This data may help providers to use more rational polypharmacy. Whereas, the reported interaction is actually less, 60%, per FAERS. Per DrugBank, the chance of an interaction is >99% once more than 3 drugs are used in combination. 3 preventives was not analyzed.Ĭonclusion: The likelihood of an interaction increases as the number of combinations of abortives and preventives increases. Due to hardware limitations, 3 abortives vs. Table 1 contains the number of interactions for a given number of medications. We downloaded DrugBank data on Augand included FAERS data from October 2012 to March 2020. Results: We included 38 abortives and 23 preventives. If at least one interaction, of any type, is listed, then it is included here and compared across the two databases. All combinations of up to 3 abortives and/or preventives are screened for interactions through DrugBank and FAERS. Methods: We included, as input, abortive and preventive drugs from the AHS Position Statement on Integrating New Migraine Treatments into Clinical Practice, as well as Szperka's, Migraine Care in the Era of COVID-19. Zhangīackground: This project aims to compare the likelihood of a theoretical drug-drug interaction between a number of abortives and preventives using DrugBank's application programing interface (API) versus the empirically reported interactions using the FDA's Adverse Event Reporting System (FAERS) API. Zhang Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States Correspondence: V.

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